An improved performance saw Luton score 4 tries and so earn their first point of the season.
Luton welcomed back scrum half Chant and fly half Winch. They also gave debuts to loose forward Williams, wing Curtis and from the bench, front row Flannery.
Datchworth newly promoted to this division made the perfect start scoring their first try in under 4 mins.
Luton responded quickly with a try of their own from Alston converted by fly half Winch.
In an evenly fought first half both teams traded scores but with the home team coming out on top, leading 23-19 at the break.
Luton added two tries from O'Grady and Staff. Winch showed his potential in the 10 shirt, but team indiscipline lead to a high penalty count and 6 points for Datchworth.
The pace slowed in the second period in part due to the hot weather. Luton brought on Chant and Yang for Willing and Williams.
A try, conversion and a penalty saw Datchworth move into a 14 point lead. But Luton cut the deficit and gave their many travelling supporters encouragement by adding a fourth try through new boy Curtis.
Luton failed to capitalise on good field positions towards the end of the game so will need to look to next weekend's game at home to newly promoted London Welsh for their first win.
First team manager Steve 'Taff' Evans said after the game: "I was disappointed that we didn’t manage to perform consistently which is what I believe cost us the match. There were flashes of brilliance in our play, but we need to do it consistently.
"We’ll now move our attention to preparing for London Welsh next Saturday. "